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Is Autophagy Dysfunction a Key to Exfoliation Glaucoma?

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In this short report we review previous work toward the identification of the protein and cellular sources of exfoliation glaucoma and described our recent finding on dysfunction of autophagy in Tenon capsule fibroblasts obtained from exfoliation syndrome glaucoma patients at the time of surgery and discuss the potential implications of these findings for understanding the cellular sources of the disease.
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Keywords: Tenon fibroblasts; autophagy; exfoliation glaucoma; lysosomes; microtubules; mitophagy

Document Type: Research Article

Affiliations: 1: Departments of Ophthalmology 2: Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 3: Departments of Ophthalmology, Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai

Publication date: March 1, 2018

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