@article {Urueña:2016:0891-3668:1339,
title = "Single-dose Universal Hepatitis A Immunization in One-year-old Children in Argentina",
journal = "The Pediatric Infectious Disease Journal",
parent_itemid = "infobike://wk/inf",
publishercode ="wk",
year = "2016",
volume = "35",
number = "12",
publication date ="2016-12-01T00:00:00",
pages = "1339-1342",
itemtype = "ARTICLE",
issn = "0891-3668",
eissn = "1532-0987",
url = "https://www.ingentaconnect.com/content/wk/inf/2016/00000035/00000012/art00020",
doi = "doi:10.1097/INF.0000000000001322",
keyword = "children, immunogenicity, long-term follow-up, Argentina, hepatitis A, single-dose vaccination",
author = "Urue{\~n}a, Anal{\’ı}a and Gonz{\’a}lez, Jorge E. and Rearte, Anal{\’ı}a and P{\’e}rez Carrega, Mar{\’ı}a E. and Calli, Rogelio and Pagani, Mar{\’ı}a F. and Uboldi, Andrea and Vicent{\’ı}n, Rosal{\’ı}a and Caglio, Patricia and Ca{\~n}ero-Velasco, Mar{\’ı}a C. and Gentile, Angela and Ramonet, Margarita and Vizzotti, Carla",
abstract = "
Background:
Single-dose hepatitis A virus (HAV) vaccination was implemented in all Argentinean children 12 months of age in 2005. Previous studies demonstrated high prevalence of protective antibody response 4 years after single-dose vaccination. This study assessed long-term
seroprotection against HAV after vaccination. 
Methods:
Children who received 1 dose of HAV vaccine at 1 year of age at least 6 years before enrollment were included at 5 centers in Argentina between 2013 and 2014. Demographic and socioeconomic characteristics were collected
through a questionnaire. Blood samples were tested for anti-HAV antibodies. Antibody values 10 mIU/mL were considered seroprotective. Logistic regression analysis was performed to evaluate the association between demographic and socioeconomic variables and seroprotection. 
Results:
A total of 1088 children were included, with a median postvaccination interval of 7.7 years (range 6.39.2 years). Of these children, 97.4% (95% confidence interval: 96.3%98.3%) had protective antibodies against HAV. No association between demographic or socioeconomic variables
and seroprotection was found. Geometric mean concentration of antibody levels against HAV was 170.5 mUI/mL (95% confidence interval: 163.2178.2 mUI/mL). 
Conclusions:
Single-dose universal hepatitis A immunization in 1-year-old children resulted in sustained immunologic
protection for up to 9 years in Argentina. These findings, along with the low current disease burden, confirm the success of the intervention.",
}