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Impact of the Increased Recommended Dosage of Isoniazid on Pyridoxine Levels in Children and Adolescents

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Isoniazid exposure causes dose-dependent pyridoxine deficiency. Recently, the recommended dosage of isoniazid in children was increased from 5 (4–6) to 10 (10–15) mg/kg/day. We aimed to analyze longitudinally pyridoxine levels in a cohort of previously healthy children and adolescents treated with isoniazid. Mild symptom-free pyridoxine deficiency was observed in 4/75 (5.6%) and 3/40 (7.5%) at baseline and at 3-month follow-up, respectively. Classical age-related risk factors identified patients at risk of pyridoxine deficiency. Our preliminary results support current recommendations regarding pyridoxine supplementation in healthy children.
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Keywords: isoniazid; peripheral neuropathy; pyridoxine; tuberculosis; vitamin B6

Document Type: Research Article

Publication date: May 1, 2016

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