Skip to main content
padlock icon - secure page this page is secure

Efficacy and Safety of 0.2% Hyaluronic Acid in the Management of Dry Eye Disease

Buy Article:

$52.00 + tax (Refund Policy)

Objectives:

To evaluate the safety and efficacy of a new artificial tear containing 0.2% hyaluronic acid, as compared with 0.9% saline solution, in mild dry eye patients after 1-month use in a crossover study design with washout periods.

Methods:

Overall, 16 mild dry eye patients were included. After a week of washout, every patient used the experimental product (Visaid 0.2%) and the control product (0.9% saline solution), each for a month (3–8 drops daily). Both products were preservative free. The percentage change for the following variables were calculated and analyzed: Ocular Surface Disease Index (OSDI) questionnaire, visual acuity, intraocular pressure, ophthalmoscopy evaluation, biomicroscopy findings, fluorescein corneal staining and lissamine green conjunctival staining, tear breakup time, contrast sensitivity, Schirmer's test, and subject satisfaction.

Results:

Patients reported an improvement (a significant decrease of −19.5%±27.5%) in OSDI scores after using Visaid 0.2% and a worsening (a significant increase of 19.2%±32.4%) after using 0.9% saline solution; the difference was significant (P=0.0087, Student's t test). Significant changes (P≤0.04, Wilcoxon's test) were found comparing Visaid 0.2% with saline solution for bulbar hyperemia (−39.1%±50.8% vs. 7.8%±12.0%, respectively), corneal staining (−26.0%±53.0% vs. 36.5%±73.3%), conjunctival staining (−54.7%±53.4% vs. −7.8%±47.2%), and subjective satisfaction (26.8%±28.5% vs. −13.3%±22.5%). There were no significant differences in the safety parameters for either solution.

Conclusion:

This clinical trial demonstrates the safety of Visaid 0.2% and its clear benefit over 0.9% saline solution.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: Dry eye disease; Dry eye management; Hyaluronic acid

Document Type: Research Article

Publication date: January 1, 2017

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more