Provider: Ingenta Connect
Database: Ingenta Connect
Content: application/x-research-info-systems
TY - ABST
AU - Achamrah, Najate
AU - Déchelotte, Pierre
AU - Coëffier, Moïse
TI - Glutamine and the regulation of intestinal permeability: from bench to bedside
JO - Current Opinion in Clinical Nutrition and Metabolic Care
PY - 2017-01-01T00:00:00///
VL - 20
IS - 1
SP - 86
EP - 91
KW - tight junction
KW - intestinal permeability
KW - gut
KW - glutamine
N2 -
Purpose of review
Glutamine is the most abundant amino acid in plasma and plays a key role in maintaining the integrity of intestinal barrier.
Recent findings
Experimental studies showed that glutamine is able to modulate intestinal permeability and tight
junction protein expression in several conditions. Recent articles underlined its putative beneficial role in gastrointestinal disorders such as irritable bowel syndrome.Summary
Glutamine is a major nutrient to maintain intestinal barrier function
in animals and humans. Depletion of glutamine results in villus atrophy, decreased expression of tight junction proteins and increased intestinal permeability. Moreover, glutamine supplementation can improve gut barrier function in several experimental conditions of injury and in some clinical
situations. Furthermore, preventive effects of glutamine in experimental models of intestinal injuries have been recently reported. Despite promising data in experimental models, further studies are needed to evaluate glutamine supplementation in clinical practice.
UR - https://www.ingentaconnect.com/content/wk/cocnm/2017/00000020/00000001/art00013
M3 - doi:10.1097/MCO.0000000000000339
UR - https://doi.org/10.1097/MCO.0000000000000339
ER -