Provider: Ingenta Connect Database: Ingenta Connect Content: application/x-research-info-systems TY - ABST AU - Achamrah, Najate AU - Déchelotte, Pierre AU - Coëffier, Moïse TI - Glutamine and the regulation of intestinal permeability: from bench to bedside JO - Current Opinion in Clinical Nutrition and Metabolic Care PY - 2017-01-01T00:00:00/// VL - 20 IS - 1 SP - 86 EP - 91 KW - tight junction KW - intestinal permeability KW - gut KW - glutamine N2 - Purpose of review

Glutamine is the most abundant amino acid in plasma and plays a key role in maintaining the integrity of intestinal barrier.

Recent findings

Experimental studies showed that glutamine is able to modulate intestinal permeability and tight junction protein expression in several conditions. Recent articles underlined its putative beneficial role in gastrointestinal disorders such as irritable bowel syndrome.Summary

Glutamine is a major nutrient to maintain intestinal barrier function in animals and humans. Depletion of glutamine results in villus atrophy, decreased expression of tight junction proteins and increased intestinal permeability. Moreover, glutamine supplementation can improve gut barrier function in several experimental conditions of injury and in some clinical situations. Furthermore, preventive effects of glutamine in experimental models of intestinal injuries have been recently reported. Despite promising data in experimental models, further studies are needed to evaluate glutamine supplementation in clinical practice.
UR - https://www.ingentaconnect.com/content/wk/cocnm/2017/00000020/00000001/art00013 M3 - doi:10.1097/MCO.0000000000000339 UR - https://doi.org/10.1097/MCO.0000000000000339 ER -