Skip to main content
padlock icon - secure page this page is secure

Glutamine and the regulation of intestinal permeability: from bench to bedside

Buy Article:

$52.00 + tax (Refund Policy)

Purpose of review

Glutamine is the most abundant amino acid in plasma and plays a key role in maintaining the integrity of intestinal barrier.

Recent findings

Experimental studies showed that glutamine is able to modulate intestinal permeability and tight junction protein expression in several conditions. Recent articles underlined its putative beneficial role in gastrointestinal disorders such as irritable bowel syndrome.Summary

Glutamine is a major nutrient to maintain intestinal barrier function in animals and humans. Depletion of glutamine results in villus atrophy, decreased expression of tight junction proteins and increased intestinal permeability. Moreover, glutamine supplementation can improve gut barrier function in several experimental conditions of injury and in some clinical situations. Furthermore, preventive effects of glutamine in experimental models of intestinal injuries have been recently reported. Despite promising data in experimental models, further studies are needed to evaluate glutamine supplementation in clinical practice.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: glutamine; gut; intestinal permeability; tight junction

Document Type: Research Article

Affiliations: Normandie Univ, INSERM UMR 1073 ‘Nutrition, Inflammation and Dysfunction of Gut-brain Axis’, University of Rouen, Nutrition Department, Rouen University Hospital, Rouen, France

Publication date: January 1, 2017

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more