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Home / Clinical Obstetrics and Gynecology, Volume 65, Number 1

Uterus Transplantation: A 50-Year Journey

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This paper provides an analysis of the last 50 years of uterus transplantation (UTx). Animal research on UTx began in the 1960s, aiming to solve tubal factor infertility. The success of in vitro fertilization shifted the focus onto uterine factor infertility. Early research in small and large animals improved following the advent of immunosuppression and established the uterus’ ability to tolerate cold ischemia and to function following vessel reanastamosis. Upon the achievement of the first live birth following UTx in 2014, human research has started to focus on reducing donor morbidity, optimal immunosuppression regimes, and the development of deceased donor UTx programmes.

Keywords: immunosuppression; in vitro fertilization; infertility; transplantation; uterus

Document Type: Research Article

Affiliations: 1: Department of Surgery and Cancer, Hammersmith Hospital, Imperial College London, West London Gynaecological Cancer Centre, Hammersmith Hospital, Imperial College NHS Trust, London, Cutrale Perioperative and Ageing Research Group, Imperial College London 2: Department of Surgery and Cancer, Hammersmith Hospital, Imperial College London, West London Gynaecological Cancer Centre, Hammersmith Hospital, Imperial College NHS Trust, London 3: The Oxford Transplant Centre, The Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford, United Kingdom

Publication date: March 20, 2022

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