@article {Karalexi:2017:0959-8278:433,
title = "Parental alcohol consumption and risk of leukemia in the offspring: a systematic review and meta-analysis",
journal = "European Journal of Cancer Prevention",
parent_itemid = "infobike://wk/cej",
publishercode ="wk",
year = "2017",
volume = "26",
number = "5",
publication date ="2017-09-01T00:00:00",
pages = "433-441",
itemtype = "ARTICLE",
issn = "0959-8278",
eissn = "1473-5709",
url = "https://www.ingentaconnect.com/content/wk/cej/2017/00000026/00000005/art00010",
doi = "doi:10.1097/CEJ.0000000000000350",
keyword = "paternal, alcohol consumption, meta-analysis, genetic polymorphisms, dose–response, maternal, pregnancy, childhood leukemia risk",
author = "Karalexi, Maria A. and Dessypris, Nick and Thomopoulos, Thomas P. and Ntouvelis, Evangelos and Kantzanou, Maria and Diamantaras, Andreas-Antonios and Moschovi, Maria and Baka, Margarita and Hatzipantelis, Emmanuel and Kourti, Maria and Polychronopoulou, Sophia and Stiakaki, Eftichia and Mora, Ana-M. and Wunsch-Filho, Victor and Infante-Rivard, Claire and Loutradis, Dimitrios and Petridou, Eleni Th.",
abstract = "Parental alcohol consumption before and during pregnancy has been linked to adverse outcomes in the offspring including leukemogenesis. We, therefore, aimed to systematically assess and quantitatively synthesize published data on the association of paternal consumption during preconception
and maternal consumption during pregnancy with leukemia risk in childhood (014 years). Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched PubMed (until February 2016) and the reference lists of the relevant studies. Observational studies
examining the association between parental alcohol consumption and childhood leukemia were considered eligible. Data extracted from 39 casecontrol studies (over 16000 leukemia cases and 30000 controls) were pooled and summary-effect estimates were calculated. Subgroup
analyses were carried out by main acute leukemia type [lymphoblastic or myeloid), cytogenetics/genetic polymorphisms, and specific alcohol beverages. We found a statistically significant doseresponse association of any level of maternal alcohol consumption compared with nondrinking
during pregnancy exclusively with acute myeloid leukemia (AML) [odds ratio (OR)moderate consumption: 1.64, 95% confidence intervals (CIs): 1.232.17 and ORhigh consumption: 2.36, 95% CI: 1.603.49]. In contrast, no association of paternal preconception consumption
with any leukemia type was noted. In beverage-specific analyses, only a positive association of maternal wine drinking with childhood AML was found, which was more pronounced in analyses including only studies on infant leukemia (ORwine: 2.12, 95% CI: 1.163.90). The largest
ever meta-analysis shows a sizeable, statistically significant doseresponse association of maternal alcohol consumption during index pregnancy with AML risk. Future research exploring the role of genetic polymorphisms is anticipated to shed light on the underlying pathophysiology.",
}