Acquired haemophilia A (AHA) is a life-threatening haemorrhagic disorder that occurs with various underlying conditions such as autoimmune disease, drug reactions, lymphoproliferative diseases, solid tumours and pregnancy/postpartum status. However, in half of all reported cases, the
underlying disease is unknown. Most AHA cases develop in adults; paediatric/adolescent cases are extremely rare. The main clinical symptom is bleeding into the skin, muscles, soft tissues and/or mucous membranes. Here, we report the case of an otherwise healthy 12-year-old girl who presented
with prolonged bleeding postexodontia. After being diagnosed with AHA, she was successfully treated with recombinant activated factor VII infusion and oral prednisolone. To avoid such unanticipated bleeding when performing dental extraction, preoperative haemostatic screening tests are recommended.
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acquired haemophilia A;
recombinant activated factor VII;
Document Type: Research Article
Department of Pediatrics, Kyoto Second Red Cross Hospital, Kyoto
Department of Regulatory Medicine for Thrombosis
Department of Pediatrics, Nara Medical University, Nara
Department of Pediatrics, Kyoto Prefectural University of Medicine
Division of Laboratory Medicine, Uji Tokushukai Medical Center, Kyoto, Japan
December 1, 2015