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Correction of factor XI deficiency by liver transplantation

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Orthotopic liver transplantation for other diseases typically results in a coincidental cure for hemophilia A and B; however, long-term outcomes of liver transplant in hemophilia C are not very well described. Herein, the authors report a patient of severe congenital factor XI (FXI) deficiency who received an orthotopic liver transplant. The authors discuss the perioperative management and long-term outcomes. The normalization of his FXI levels confirms that the liver is the most clinically relevant site of synthesis of FXI.
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Keywords: bleeding; clotting factors; factor XI deficiency; hemophilia; liver transplant

Document Type: Research Article

Affiliations: 1: Division of Hematology and Oncology 2: Division of Laboratory Medicine and Pathology, –Jacksonville, Florida 3: Division of Hematology and Oncology, Mayo Clinic, Rochester, Minnesota, USA

Publication date: December 1, 2015

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