@article {Shigekiyo:2015:0957-5235:956,
title = "Factor VII Tokushima: the first case of factor VII Cys22Gly with the development of myocardial infarction in the proband receiving recombinant factor VIIa replacement therapy",
journal = "Blood Coagulation & Fibrinolysis",
parent_itemid = "infobike://wk/blcof",
publishercode ="wk",
year = "2015",
volume = "26",
number = "8",
publication date ="2015-12-01T00:00:00",
pages = "956-958",
itemtype = "ARTICLE",
issn = "0957-5235",
eissn = "1473-5733",
url = "https://www.ingentaconnect.com/content/wk/blcof/2015/00000026/00000008/art00020",
doi = "doi:10.1097/MBC.0000000000000346",
keyword = "factor VII deficiency, myocardial infarction, recombinant factor VIIa, factor VII mutation",
author = "Shigekiyo, Toshio and Sekimoto, Etsuko and Shibata, Hironobu and Ozaki, Shuji and Okumura, Takanobu and Fujinaga, Hiroyuki and Shibata, Hiroshi and Aihara, Ken-ichi and Akaike, Masashi",
abstract = "An 81-year-old man was referred to our department because of suspected factor VII (FVII) deficiency. His FVII activity was under 1%, whereas the FVII activity levels of his son and granddaughter were 65 and 109%, respectively. The nucleotide at position 3886 of his FVII gene
was homozygous for G. A single T to G substitution results in the replacement of wild-type Cys at residue 22 by Gly. His son was heterozygous for G and T at position 3886, whereas his granddaughter was homozygous for wild-type T. These results suggest that he was homozygous for FVII Cys22Gly.
He underwent radiofrequency ablation (RFA) for hepatocellular carcinoma, receiving 20g/kg of recombinant FVIIa prior to RFA and 10g/kg of recombinant FVIIa twice after RFA. He showed no bleeding tendency; however, a myocardial infarction was diagnosed and percutaneous coronary
intervention was performed.",
}