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Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation

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ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, and has not been documented in any other salivary tumor type. The present study comprised a clinical, histologic, and molecular analysis of 10 cases of secretory carcinoma, with typical morphology and immunoprofile harboring a novel ETV6-RET translocation.
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Keywords: ETV6-NTRK3; ETV6-RET fusion transcript; MASC; mammary analog secretory carcinoma; salivary

Document Type: Research Article

Affiliations: 1: Departments of Pathology, Bioptic Laboratory Ltd 2: Bioptic Laboratory Ltd, Molecular Pathology Laboratory 3: Department of Pathology, University Health Network, Toronto, ON, Canada 4: Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 5: Department of Anatomical Pathology, University of Calgary and Foothills Medical Centre, Calgary, AB 6: Department of Pathology and Molecular Medicine, St. Joseph’s Healthcare & Hamilton Health Sciences, McMaster University, Vancouver, BC, Canada 7: Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland 8: Departments of Pathology, Biomedical Center, Faculty of Medicine in Pilsen, Charles University 9: Otorhinolaryngology 10: Oncology and Radiotherapy, Oncological Clinic 11: Clinical Oncology, Oncological Clinic, Faculty of Medicine in Plzen 12: Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran 13: Bioptic Laboratory Ltd, Molecular Pathology Laboratory, Faculty of Education, University of West Bohemia, Plzen, Czech Republic 14: Ignyta Inc. San Diego, California, United States 15: Departments of Pathology, Bioptic Laboratory Ltd, Molecular Pathology Laboratory 16: Departments of Pathology

Publication date: February 1, 2018

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