Sinonasal epithelial hamartomas occurring in adults are classified as seromucinous hamartoma (SMH) or respiratory epithelial adenomatoid hamartoma (REAH). We describe herein a novel subtype of adult sinonasal hamartoma that contains olfactory epithelium, a histologic feature not previously
reported in the literature. Our pathology department database was retrospectively searched for sinonasal hamartomas containing areas of olfactory epithelium. Six relevant cases (3 male and 3 female patients; age, 30 to 77 y) were retrieved, and available pathology slides and clinical
and imaging data from patient charts were reviewed. Five of the lesions were unilateral solitary, polypoid, pedunculated masses, 38 to 80 mm in length, lodged in the nasal olfactory cleft. The sixth lesion was associated with bilateral nasal polyposis, and its precise localization was
not known. All patients were treated by transnasal endoscopic surgery. None of the 3 patients who had received adequate follow-up evaluation exhibited recurrence. Histologically, all lesions resembled SMH or REAH, with areas of olfactory epithelium comprising olfactory receptors and sustentacular
and basal cells. Olfactory epithelium was observed at the lesion surface or in invaginated gland-like structures, and it contained focal aggregates of filamentous cell processes. Some olfactory receptor cells or cell processes were also present in the seromucinous gland component of lesions.
Olfactory receptor cells expressed CD56 (neural cell adhesion molecule), and the filamentous aggregates contained CD56, neurofilaments, and synaptophysin. Aside from SMH and REAH, we have described a third subtype of adult sinonasal hamartoma—olfactory epithelial hamartoma—which
shares the benign character of the other 2.
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olfactory epithelial hamartoma;
olfactory receptor cells;
Document Type: Research Article
Departments of Pathology, Faculty of Medicine, Paris Diderot University
Department of Pathology, Assistance Publique, Hopitaux de Paris, Tenon Hospital, Paris France
Faculty of Medicine, Paris Diderot University, Otolaryngology, Head and Neck Surgery, Assistance Publique, Hopitaux de Paris, Lariboisière Hospital
Otolaryngology, Head and Neck Surgery, Assistance Publique, Hopitaux de Paris, Lariboisière Hospital
Publication date: January 1, 2018