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Antiretroviral initiation is associated with increased skeletal muscle area and fat content

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A greater burden of physical function impairment occurs in HIV-infected adults; the impact of antiretroviral therapy (ART) initiation on muscle density (less dense = more fat), a measure of muscle quality, is unknown.


AIDS Clinical Trials Group Study A5260s, a cardiometabolic substudy of A5257, randomized HIV-infected, ART-naive adults to ritonavir-boosted atazanavir, darunavir, or raltegravir with tenofovir/emtricitabine backbone. Single-slice abdominal computed tomography scans from baseline and week 96 were reanalyzed for total and lean muscle area and density.Methods:

Two-sample t-tests described the differences between baseline and week 96 variables. Linear regression analysis was used to explore the role of a priori identified variables and potential confounders.

Participants (n = 235) were mostly men (90%); 31% were Black non-Hispanic; 21% were Hispanic. Over 96 weeks, small but significant increases were seen in oblique/transverse abdominal, rectus, and psoas muscle total area (range 0.21–0.83 cm2; P < 0.05) but not the lean muscle component (all P ≥ 0.33). Significant decreases in overall density, consistent with increases in fat, were seen in all muscle groups (range −0.87 to −2.4 HU; P < 0.01); for the lean muscle component, only decreases in oblique/transverse abdominal and rectus reached statistical significance (P < 0.05). In multivariable analyses, Black race was associated with increased muscle density and female sex with decreased density; treatment arm was not associated with changes in mass or density.

The ART-associated increase in muscle area, regardless of regimen, is likely a reflection of increased fat within the muscle. The consequences of fatty infiltration of muscle on subsequent muscle function require further investigation.
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Keywords: HIV; aging; frailty; muscle density; skeletal muscle

Document Type: Research Article

Affiliations: 1: University of Colorado Anschutz Medical Campus, Aurora, Colorado 2: Case Western University, Cleveland, Ohio 3: University of Texas Health Sciences Center, Houston, Texas 4: University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 5: University of California, Los Angeles, California 6: Johns Hopkins University, Baltimore, Maryland, USA.

Publication date: August 24, 2017

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