Data from the past 6 years have shown that the presence of any amount of cribriform (or more comprehensively, large acinar cribriform to papillary) pattern of invasive prostate cancer is associated with adverse pathologic features and leads to uniquely adverse outcomes. Sixteen papers
and numerous abstracts have reached these conclusions concordantly. Not only does this justify removal of all cribriform cancer from Gleason grade 3, it shows that cribriform cancer has pathologic, outcome, and molecular features distinct from noncribriform Gleason grade 4. Suggestions for
accommodating the presence of cribriform cancer into the 2014 Grade Group scheme are proposed.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
Document Type: Research Article
Department of Pathology, Medical College of Wisconsin, Milwaukee, WI
Department of Pathology, University of Chicago, Chicago, IL
Department of Pathology, University Health Network, Toronto, Ontario, Canada
January 1, 2018