Polychlorinated biphenyls (PCBs) and dibenzofurans (PCDFs) are persistent environmental pollutants shown to adversely interact with several functions of the endocrine system. In 1978–1979, over 2000 Taiwanese people ingested rice oil accidentally contaminated with PCBs and PCDFs.
This is one of the major toxic exposure episodes that occurred globally and was later called Yucheng (oil disease in Chinese). The children born to exposed Yucheng women were therefore exposed in utero to high doses of PCBs/PCDFs. In 1995, 60 Yucheng and 61 control boys participated in physical
examination, and serum hormones were measured by radioimmunoassay (RIA). Age, body weight, body height, Tanner status, testicular size, serum luteinizing hormone (LH), prolactin (PRL), thyroxine (T 4 ), triiodothyronine (T 3 ), and thyroid-stimulating hormone (TSH) levels were not statistically
different between Yucheng and control boys in the subgroups of before and at the age of puberty. However, the serum estradiol (E 2 ) levels were significant higher in Yucheng boys at the age of puberty. Yucheng and control boys were further divided into two subgroups, those before (age
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Document Type: Research Article
Department of Safety, Health and Environmental Engineering, National Kaohsiung First University of Science and Technology, Kaohsiung, Taiwan
Department of Psychiatry, Chung-Shan Medical University Hospital, Taichung, Taiwan
Department of Psychology, Kaohsiung Medical University, Kaohsiung, Taiwan
NTH/USEPA Center for Childhood Neurotoxicology and Exposure Assessment and the Department of Pediatrics, University of Medicine and Dentistry of New Jersey and Rutgers University, One Robert Wood Johnson Place, New Brunswick, NJ, USA
Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan
Publication date: 01 September 2005
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