Chronic lymphoplasmacytic gastritis in two red-capped mangabeys (Cercocebus torquatus) at a zoological facility progressed to severe hypertrophic gastropathy similar to Ménétrier's disease that affects humans. Clinical signs included emesis, diarrhea, hunched posture
consistent with abdominal pain, anemia, and hypoproteinemia. Large gastric masses were present and in one case created a gastric outflow obstruction. Both cases were positive for simian immunodeficiency virus and Helicobacter spp. were variably isolated, although the association with
the hypertrophic gastropathy is unclear. Medical treatment had varying success and included sucralfate, H2 receptor antagonists, proton pump inhibitors, diet manipulations, and antibiotic therapies targeting Helicobacter spp. Surgical resection of a large portion of the stomach resulted
in some palliative improvement in one case. Overall, this disease presented many challenges regarding identification, confirmation of diagnosis, and clinical management. Both aggressive medical and surgical treatments were unrewarding for long-term management of hypertrophic gastropathy in
this pair of red-capped mangabeys and resulted in a poor prognosis in these cases.
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Document Type: Research Article
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Illinois, 2001 S. Lincoln Avenue, Urbana, IL, 61802, USA
Chicago Zoological Society, Brookfield Zoo, 8400 W. 31st Street, Brookfield, IL, 60513, USA
Zoological Pathology Program, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, S. First Avenue, Maywood, IL, 60153, USA
Publication date: 02 January 2014