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Novel approach to control sulfamethazine misuse in food-producing animals by hair analysis

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The presence of sulfamethazine residues in pig and calf hair was compared with the residual levels encountered in the corresponding edible tissues (liver and muscle) as a consequence of drug administration. Sulfamethazine up to 84.7mgkg −1 was found in calf hair samples after a pharmacological treatment, with a significant effect of hair pigmentation. High concentrations of the parent drug were detected in calf hair for 4 weeks after administration, when sulfamethazine residues were no longer detectable in the corresponding edible tissues. In a similar way, pig hair also accumulated sulfamethazine residues up to 40.5mgkg −1 , which was more than the amount detected in the corresponding muscle and liver samples at slaughter. Hair analysis seems a suitable tool to improve the efficacy of regulatory controls, and thus the safety of the food chain and to discourage the improper use of sulfamethazine in animal farming.
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Keywords: HPLC; Hair analysis; residue detection; sulfamethazine

Document Type: Research Article

Affiliations: IRTA-CTC, Food Chemistry Unit, Granja Camps i Armet s/n, E-17121 Monells, Girona, Spain

Publication date: October 1, 2006

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