An analogue of acetildenafil was detected in an extract of pre-mixed bulk powder. To our knowledge, the powder was destined to be encapsulated and sold as a dietary supplement. The structure was identified by NMR, HR-ESI–MS, ESI–MS n and FTIR analyses. Owing to the inclusion of a hydroxyl group in acetildenafil, the detected compound was called ‘hydroxyacetildenafil'. With increasing use of dietary supplements marketed for penile erectile dysfunction, the detection of analogues of sexual performance enhancers is important and timely.
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electrospray ionization (ESI);
Document Type: Research Article
Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543
Centre for Analytical Sciences, Health Sciences Authority, 11 Outram Road, Singapore 169078
September 1, 2006
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