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Home / Synthetic Communications, Volume 35, Number 18

Synthesis of New N‐(5‐Oxo‐2,5‐dihydro)pyrrol‐3‐yl Glycines and N‐(5‐Oxo‐2,5‐dihydro)pyrrol‐3‐yl Glycines Esters

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Authors: Jourdan, Fabrice 1 ; Kaiser, Jens 2 ; Lowe, David 3 ; 

Source: Synthetic Communications, Volume 35, Number 18, Number 18/2005, pp. 2453-2466(14)

Publisher: Taylor and Francis Ltd

DOI: https://doi.org/10.1080/00397910500191219

Following our efforts towards the synthesis of new potential inhibitors of Xanthine Dehydrogenase (XDH), we describe here a general method for the preparation of N-(5-oxo-2,5-dihydro)pyrrol-3-yl glycines and N-(5-oxo-2,5-dihydro)pyrrol-3-yl glycine esters from glycine ethyl ester hydrochloride and various 4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid esters and carbonitriles.

Keywords: 5-oxopyrrol-3-ylglycine; Xanthine dehydrogenase; amino acid

Document Type: Research Article

Affiliations: 1: University of Bath, Department of Pharmacy and Pharmacology, Claverton Down, Bath, UK 2: Max Planck Institut für Biochemie, Martinsried, Germany 3: John Innes Centre, Department of Biological Chemistry, Colney, Norwich, UK

Publication date: 01 January 2005

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