A reversed phased HPLC method with photodiode array detection was used to monitor the stability of opioid growth factor (OGF; [Met 5 ]-enkephalin) in sterile saline for 1, 2, and 8 weeks, and stored at -17°C, 4°C, and 23°C. Samples maintained at -17°C had 97% of the initial OGF concentration after 2 months, whereas those stored at 4°C had 94% of the original concentration. Preparations housed at 22°C had reductions of 6–12% by the 8th week. These data provide important information about storage of OGF for clinical applications.
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Opioid growth factor;
Document Type: Research Article
Department of Comparative Medicine, Penn State University College of Medicine, Hershey, Pennsylvania
Department of Neural and Behavioral Sciences, Penn State University College of Medicine, Hershey, Pennsylvania
Telz Stone, Israel
January 1, 2006