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Approximate Bayesian inference for quantiles

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Suppose data consist of a random sample from a distribution function F Y , which is unknown, and that interest focuses on inferences on ?, a vector of quantiles of F Y . When the likelihood function is not fully specified, a posterior density cannot be calculated and Bayesian inference is difficult. This article considers an approach which relies on a substitution likelihood characterized by a vector of quantiles. Properties of the substitution likelihood are investigated, strategies for prior elicitation are presented, and a general framework is proposed for quantile regression modeling. Posterior computation proceeds via a Metropolis algorithm that utilizes a normal approximation to the posterior. Results from a simulation study are presented, and the methods are illustrated through application to data from a genotoxicity experiment.

Keywords: Comet assay; Median regression; Nonparametric; Order constraints; Prior elicitation; Quantile regression; Single-cell electrophoresis; Substitution likelihood

Document Type: Research Article

Affiliations: 1: Biostatistics Branch, MD A3-03, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC, 27709, USA 2: Epidemiology Branch, MD A3-03, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC, 27709, USA

Publication date: 01 April 2005

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