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In vitro antitumor activity of triterpenes from Ceriops tagal

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The embryo of Ceriops tagal was extracted with 95% ethanol at room temperature, and four triterpenes (1-4) were separated from this extract. For the first time these triterpenes were the separated from this plant. Compounds (1-4) were tested in vitro for antitumor activity against three cell lines (human liver cancer cell (H-7402), human B-lymphoblastoid cell (Raji), and human cervical carcinoma cell (Hela)). Compounds 1 and 3 were effective to inhibit cell proliferation and growth of H-7402 and Hela, the IC50 of them on H-7402 were 14.42 µg mL-1 and 9.97 µg mL-1, and the IC50 of them on Hela were 11.84 µg mL-1 and 11.32 µg mL-1. All compounds 1-4 were not effective to inhibit cell proliferation and growth of Raji. The effects of compound 4 on inhibiting proliferation and growth of these three cancer cells was also not obvious.
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Keywords: Antitumor; Ceriops tagal; Rhizophoraceae; Triterpenes

Document Type: Research Article

Affiliations: Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academic of Sciences, Guangzhou 510301, China

Publication date: December 1, 2007

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