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Comparative studies on the camptothecin content from Nothapodytes foetida and Ophiorrhiza species

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Camptothecin is an anticancer quinoline alkaloid effective against colon cancer. It acts by inhibition of the enzyme DNA topoisomerase I. A comparative study of camptothecin from the indigenous plants namely Nothapodytes foetida, Ophiorrhiza mungos and Ophiorrhiza rugosa indicated highest yields of camptothecin and 9-methoxy camptothecin in N. foetida. The other two plants O. mungos and O. rugosa contained low levels of alkaloids.
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Keywords: Camptothecin; Medicinal plants; Nothapodytes foetida; Ophiorrhiza mungos; Ophiorrhiza rugosa

Document Type: Research Article

Affiliations: Plant Biotechnology and Secondary Products Section, Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India

Publication date: 01 January 2006

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