Metallurgy processes are associated with many hazardous and toxic factors, including heavy metals. Exposure to heavy metals can cause damage to different organs, which can be observed through variation in the concentration of proteins in serum. The aim of this study was to evaluate
the changes in a serum protein profile of copper smelters exposed to As, Cd and Pb ions, and xenobiotics present in tobacco smoke. A 2.3-fold higher Pb concentration in the blood and a 2.8-fold greater As concentration have been observed in the urine of non-smoking smelters compared to a control
group. In the blood of smoking smelters, Cd concentration was 2-fold higher than in non-smoking ones. Serum proteins were separated by capillary electrophoresis, and in the group of non-smoking smelters, a higher amount of α1-globulins was observed. In the group of smoking
smelters, fewer α1-globulins were noted. Furthermore, a greater amount of α2-globulins in the serum of smoking and non-smoking workers in relation to the control group was revealed. A positive correlation between the concentration of Cd in the blood and the
content of a fraction containing α1- and α2-globulins was revealed. Urine Cd concentration was found to be negatively associated with the α1- and α2-globulins fraction. Observed abnormalities in the proteins profiles of smelters
can be important markers when assessing exposure to heavy metals and in the early diagnosis of diseases caused by them.
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serum proteins profile
Document Type: Research Article
Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, 50-556, Poland
Students Scientific Association, Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, 50-556, Poland
AB Sciex Sp. z o.o, ., Warsaw, 00-120, Poland
December 8, 2014
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