Skip to main content
padlock icon - secure page this page is secure

Capillary electrophoretic separation of serum proteins of workers occupationally exposed to heavy metals

Buy Article:

$61.00 + tax (Refund Policy)

Metallurgy processes are associated with many hazardous and toxic factors, including heavy metals. Exposure to heavy metals can cause damage to different organs, which can be observed through variation in the concentration of proteins in serum. The aim of this study was to evaluate the changes in a serum protein profile of copper smelters exposed to As, Cd and Pb ions, and xenobiotics present in tobacco smoke. A 2.3-fold higher Pb concentration in the blood and a 2.8-fold greater As concentration have been observed in the urine of non-smoking smelters compared to a control group. In the blood of smoking smelters, Cd concentration was 2-fold higher than in non-smoking ones. Serum proteins were separated by capillary electrophoresis, and in the group of non-smoking smelters, a higher amount of α1-globulins was observed. In the group of smoking smelters, fewer α1-globulins were noted. Furthermore, a greater amount of α2-globulins in the serum of smoking and non-smoking workers in relation to the control group was revealed. A positive correlation between the concentration of Cd in the blood and the content of a fraction containing α1- and α2-globulins was revealed. Urine Cd concentration was found to be negatively associated with the α1- and α2-globulins fraction. Observed abnormalities in the proteins profiles of smelters can be important markers when assessing exposure to heavy metals and in the early diagnosis of diseases caused by them.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: capillary electrophoresis; heavy metals; serum proteins profile

Document Type: Research Article

Affiliations: 1: Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, 50-556, Poland 2: Students Scientific Association, Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, 50-556, Poland 3: AB Sciex Sp. z o.o, ., Warsaw, 00-120, Poland

Publication date: December 8, 2014

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more