Perfluorooctanesulphonyl fluoride (PFOSF), as a main precursor of perfluorooctanesulphonate (PFOS) that is ubiquitous in the environment, has been released to the environment with substantial quantity. Determination of PFOSF presents significant analytical challenges for using liquid
chromatography with UV (LC–UV) and fluorescence detection (LC–FLD) due to the lack of chromophore in the molecular structure. In this study, a new method was developed by derivatising PFOSF with 1-naphthol to form 1-naphthylperfluorooctanesulphonate (NPFOS), which allowed rapid
qualitative and quantitative analysis using LC–UV and LC–FLD. The derivatising product was confirmed from the analyses by proton nuclear magnetic resonance and quadrupole–time of flight mass spectrometry. The LC–FLD method demonstrated good linearity in the NPFOS concentration
range from 20 pg µL−1 to 20 ng µL−
1 with a correlation coefficient better than 0.999, with the instrument detection limit of 1.5 pg µL−
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Document Type: Research Article
State Key Laboratory of Environmental and Biological Analysis and Department of Chemistry, Hong Kong Baptist University, Hong Kong SAR, China
California Department of Public Health, Richmond, CA, 94804, USA
December 8, 2014
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