An improved single-drop microextraction method for the determination of thiophanate-methyl and chlorotoluron in water samples was developed, with analysis by high-performance liquid chromatography-ultraviolet detection (HPLC-UV). Several parameters such as solvent type, salt concentration, stirring rate, extraction time, pH and organic drop volume were investigated. The optimum experimental conditions found were: 20 µL 1-octanol, 10% (w/v) NaCl, 600 rpm stirring rate, 40 min extraction time, neutral sample pH and 5 mL water sample. Under the optimum conditions, the enrichment factors were 45.3 and 107.0 folds for thiophanate-methyl and chlorotoluron, respectively. The method exhibited a wide linear range (1-100 µg L-1), reasonable detection limits (0.35 µg L-1) and suitable repeatability (RSD < 9.6%) for both analytes. The proposed method was validated with three real water samples fortified at two levels, and reasonable spiked recoveries were achieved in the range of 84.0% ∼ 110.3%. The experimental results indicated that the improved SDME was a simple, reliable and convenient technique and could easily be used for the enrichment of other pollutants.
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improved single-drop microextraction;
Document Type: Research Article
School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, Henan, China
State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, China
June 1, 2008
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