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The Analysis of Methyl Isocyanate using Secondary Amines by GC-FID

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The purpose of this study is to develop a convenient and novel method using the derivatization reaction of methyl isocyanate (MIC) with secondary amines such as dipropylamine, dibutylamine, dipentylamine, pyrazole, morpholine, piperidine, pyrrolidine and 1-methylpiperazine by gas chromatography with flame ionization detector.

The urea derivatives derived quantitatively and simultaneously from MIC and secondary amines in methylene chloride are confirmed by thin layer chromatography (TLC) and gas chromatography with mass selective detector (GC-MSD), thermoionic detector (GC-TID) and flame ionization detector (GC-FID).

TLC R f values of N-methyl-NN′-dipropylurea (MDPU), N-methyl-NN′-dibutylurea (MDBU), and N-methyl-NN′-dipentylurea (MDAU) in methylene chloride are 0.40, 0.44, and 0.49, respectively. The molecular ions of MDPU, MDBU, MDAU, MIC-morpholine, MIC-pyrazole, MIC-piperidine, MIC-pyrrolidine, and MIC-1-methylpiperazine are 158, 186, 214, 144, 125, 142, 128, and 157, respectively. The detection limit for MDPU, MDBU, and MDAU by GC-FID was 15-20 ng per sample.
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Keywords: 1-Methylpiperazine; Dibutylamine (DBA); Dipentylamine (DAA); Dipropylamine (DPA); GC-FID; GC-MSD; Methyl isocyanate; Morpholine; Piperidine; Pyrazole; Pyrrolidine; TLC

Document Type: Research Article

Affiliations: Department of Industrial Environment Health, College of Health Science, Yonsei University 234, Maeji-ri, Hungob-myon, Wonju-si, Kangwon-do, 220-710, Republic of Korea

Publication date: March 1, 2003

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