Skip to main content
padlock icon - secure page this page is secure

An Incremental Retinal-Defocus Theory of the Development of Myopia

Buy Article:

$60.00 + tax (Refund Policy)

Previous theories of myopia development involved subtle and complex processes such as the sensing and analyzing of chromatic aberration, spherical aberration, spatial gradient of blur, and spatial frequency content of the retinal image. However, these theories have not been able to explain all the diverse experimental results, which has been accomplished by our newly proposed incremental retinal-defocus theory. Our theory is based on a relatively simple and direct mechanism for the regulation of ocular growth. It states that a time-averaged decrease in retinal-image defocus decreases the rate of release of retinal neuromodulators, which decreases the rate of retinal proteoglycan synthesis, with an associated decrease in scleral structural integrity. This increases the rate of scleral growth, and in turn the eye's axial length, which produces permanent myopia. Schematic analysis of the theory has provided a clear explanation for the eye's ability to grow in the appropriate direction under a wide range of experimental conditions. In addition, the theory has been able to explain how repeated cycles of nearwork-induced transient myopia leads to repeated periods of decrease in retinal-image defocus, whose cumulative effect over an extended period of time also results in an increase in axial growth that produces permanent myopia. Thus, this unifying theory forms the basis for understanding the underlying retinal and scleral mechanisms of myopia development.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: emmetropization; myopia; nearwork-induced transient myopia; ocular axial length; refractive error; retinal defocus

Document Type: Research Article

Affiliations: 1: Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, USA 2: Department of Vision Sciences, State University of New York, State College of Optometry, New York, New York, USA

Publication date: July 1, 2003

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more