@article {Lin:2019:0095-8972:987,
title = "Synthesis, characterization and cytotoxic activity of diorganotin complexes with Schiff base derived from salicylaldehyde and l-tyrosine",
journal = "Journal of Coordination Chemistry",
parent_itemid = "infobike://tandf/gcoo",
publishercode ="tandf",
year = "2019",
volume = "72",
number = "5-6",
publication date ="2019-04-03T00:00:00",
pages = "987-1001",
itemtype = "ARTICLE",
issn = "0095-8972",
eissn = "1029-0389",
url = "https://www.ingentaconnect.com/content/tandf/gcoo/2019/00000072/f0030005/art00015",
doi = "doi:10.1080/00958972.2019.1584796",
keyword = "complex, cytotoxic activity, Schiff base, Organotin, crystal structure",
author = "Lin, Yichao and An, Wugai and Ge, Xingxing and Liu, Mingzhu and Wang, Yue and Liu, Xicheng and Tian, Laijin",
abstract = "Seven diorganotin complexes with the Schiff bases derived from salicylaldehyde and l-tyrosine, R2Sn[2-O-5-XC6H3CH=NCH(CH2C6 H4OH-4)COO] (X=H (1), Br (2); R=Me
(a), Et (b), Bu (c), Cy (cyclohexyl) (d)), were synthesized and characterized by elemental analysis, IR, 1H and 13C NMR spectra, and the single-crystal X-ray diffraction. In methanol, the racemization of chiral center of l-tyrosinate
fragment occurred and the racemic products were obtained. X-ray analyses of 1c, 1d, and 2a2c showed that the tin atoms of the complexes exhibit distorted trigonal-bipyramidal geometries. In 1c, 1d, and 2c, the intermolecular OHO
hydrogen bonds connected the molecules into 1-D supramolecular chain or a R
2
2(20) macrocyclic dimer, and 2a and 2b formed the 2-D supramolecular network by the intermolecular SnO and OHO interactions. Bioassay
results indicated that 1a, 1c, and 1d had moderate antibacterial activity against Escherichia coli and 1c, 1d, and 2c belonged to the efficient cytostatic agents against two human tumor cell lines (A549 and HeLa) and the activity tends to follow
the order Cy > Bu>Et>Me for the R group attached to tin.",
}