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Synthesis, structure and antitumor activity of the binuclear tetranitrosyl iron complex with 2-mercaptobenzthiazole – the nitric oxide donor (NO)

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Single-crystals of binuclear neutral sulfur-nitrosyl iron complex with 2-mercaptobenzthiazole ligand [Fe27н4NS2)2(NO)4] (BTz) have been obtained. From X-ray data, BTz has a centrosymmetric dimeric structure, with the iron atoms being linked through the ยต-N-C-S bridge. As follows from mass-spectra of the BTz gas phase, the complex is stable in the crystalline state under normal conditions (ambient temperature and standard humidity) and releases nitric oxide upon heating. Using amperometry, kinetics of NO release by BTz in 1% dimethyl sulfoxide aqueous solution has been studied: release of NO was shown to occur immediately upon dissolution in protic media. BTz inhibited growth of K562 leukemia and SKOV3 ovarian carcinoma cells in vitro and induced apoptosis via activation caspases 3 and 7.
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Keywords: 2-Mercaptobenzthiazole; Nitrosyl iron complexes; apoptosis induction; nitric oxide donation

Document Type: Research Article

Affiliations: 1: Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russia; 2: N.N. Blokhin Cancer Research Center, Russian Ministry of Health, Moscow, Russia

Publication date: April 3, 2019

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