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Structural aspects of a trimetallic CuII derivative: cytotoxicity and anti-proliferative activity on human cancer cell lines

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A trimetallic CuII derivative, [Cu3(L)2(CF3COO)2] (1) (where H2L = N,N′-bis(salicylidene)-1,3-propanediamine), was prepared and characterized. In 1, the two terminal CuII ions are linked to the central CuII by trifluoroacetato and doubly bridging phenoxido. Both the square-pyramidal and octahedral geometries are observed among two different CuII centers in the linear arrangement of the trimetallic unit. Compound 1 is characterized by IR and UV-Vis spectra. Compound 1 has high cytotoxic activity in breast adenocarcinoma (MCF-7), colorectal carcinoma (HCT116) and particularly, in ovarian carcinoma (A2780) cell line compared to a lung adenocarcinoma cell line. The IC50 in A2780 cells is 25 times lower than the respective value for normal human primary fibroblasts demonstrating 1 has higher cytotoxicity towards cancer cells. Additionally, combination of DOX with 1 induces a higher loss of HCT116 cell viability compared with each drug alone.
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Keywords: Copper(II); DOX; cancer cell lines; cytotoxicity; trimetallic

Document Type: Research Article

Affiliations: 1: Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan; 2: Dipartimento di Chimica, Universita degli Studi di Parma, Parma, Italy; 3: UCIBO, DCV, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal;

Publication date: April 3, 2019

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