A trimetallic CuII derivative, [Cu3(L)2(CF3COO)2] (1) (where H2L = N,N′-bis(salicylidene)-1,3-propanediamine), was prepared and characterized. In 1, the two terminal CuII ions are
linked to the central CuII by trifluoroacetato and doubly bridging phenoxido. Both the square-pyramidal and octahedral geometries are observed among two different CuII centers in the linear arrangement of the trimetallic unit. Compound 1 is characterized by IR
and UV-Vis spectra. Compound 1 has high cytotoxic activity in breast adenocarcinoma (MCF-7), colorectal carcinoma (HCT116) and particularly, in ovarian carcinoma (A2780) cell line compared to a lung adenocarcinoma cell line. The IC50 in A2780 cells is 25 times lower than
the respective value for normal human primary fibroblasts demonstrating 1 has higher cytotoxicity towards cancer cells. Additionally, combination of DOX with 1 induces a higher loss of HCT116 cell viability compared with each drug alone.
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cancer cell lines;
Document Type: Research Article
Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan;
Dipartimento di Chimica, Universita degli Studi di Parma, Parma, Italy;
UCIBO, DCV, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal;
April 3, 2019