Studies on the interaction of aquacobalamin with cysteinesulfinic and cysteic acids, hypotaurine and taurine
This study reports results of kinetic and mechanistic studies on the reactions of aquacobalamin (H2OCbl+) with oxo-derivatives of cysteine, that is, cysteinesulfinic and cysteic acids, hypotaurine and taurine. The reactions with cysteinesulfinic acid and hypotaurine result in formation of S-bound complexes, whereas cysteic acid and taurine are coordinated with aquacobalamin via amino-group. Reaction of taurine with H2OCbl+ produces a substantially more stable complex than with cysteic acid, whereas the affinity of cysteinesulfinic acid toward aquacobalamin is slightly higher than that of hypotaurine.
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