Skip to main content
padlock icon - secure page this page is secure

Biological evaluation of redox stable cisplatin/Cu(II)-DNA adducts as potential anticancer agents

Buy Article:

$60.00 + tax (Refund Policy)

A series of non-enolizable β-diketonate-based copper(II) complexes with LCuCl2 [L¬†=¬†Knoevenagel condensates of curcumin (Salcimine) and methylacetoacetate (SalMaA)-based Schiff bases] chromospheres as functional models of chemotherapy drug cisplatin were investigated for their covalent interaction with herring sperm DNA. The synthesis and structural characterization of 1a and 1b have been reported in our previous article. However, their DNA interactions and cytotoxicity properties were not studied. These analyses have been carried out mainly through electrochemical techniques supplemented with spectral, relative viscosity, gel electrophoresis techniques, and AGS cancer cells using MTT assay. The cytotoxic activities of the ligand, curcumin-based copper complex, and cisplatin were tested against the AGS cancer cell line under similar experimental conditions showing that the complex exhibited cancer cell inhibitory rate closer to cisplatin even at low concentration. This was also seen in the docking of the Cu-complex onto a rich guanine B-DNA decamer, where a Cu–N3(guanine) interaction instead of Pt-N7 as cisplatin is detected. The obtained results in this study prove that these complexes could be a promising substitute for cisplatin as a new family of non-platinum-based anticancer metallo-drugs after in vivo tests on animal models.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: Copper complexes; DNA-binding; MTT assay; cytotoxicity; molecular docking

Document Type: Research Article

Affiliations: 1: Department of Materials Science, School of Chemistry, Madurai Kamaraj University, Madurai, India 2: Department of Chemistry, Sourastra College, Madurai, India 3: Department of Genetics, School of Biological Sciences, Madurai Kamaraj University, Madurai, India 4: Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India 5: Department of Microbial Technology, School of Biological Sciences, Madurai Kamaraj University, Madurai, India

Publication date: January 17, 2016

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more