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Synthesis, characterization, and biological evaluation of silver(I) complexes of N′-(1-(pyrazin-2-yl)ethylidene)picolinohydrazide

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Three Ag+ complexes, [Ag(L)(NO3)]n (1), {[Ag(L)]·SbF6·CH2Cl2}n (2), and {[Ag(L)]·SO3CF3·CHCl3}n (3), based on a hydrazone ligand L have been obtained (L = N′-(1-(pyrazin-2-yl)ethylidene)picolinohydrazide) and characterized. Complexes 13 all show 1-D chain-like structures. Their antibacterial activity and interaction with serum albumin were investigated. These results indicate that these complexes show good antibacterial activities and binding affinity to serum albumin.
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Keywords: Ag+ complexes; Hydrazone; antibacterial activity; serum albumin interaction

Document Type: Research Article

Affiliations: School of Life Sciences, Shandong University of Technology, Zibo, People’s Republic of China

Publication date: January 17, 2016

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