Skip to main content
padlock icon - secure page this page is secure

Influence of metal complex formation on the antimicrobial activity of nifuroxazide: spectroscopic, electrochemical, and DFT studies

Buy Article:

$60.00 + tax (Refund Policy)

[M(HL)2] complexes (M = Co(II) (1), Ni(II) (2), and Cu(II) (3); H2L = 4-hydroxybenzoic[(5-nitro-2-furanyl)methylene]hydrazide acid, nifuroxazide) were synthesized, characterized (by elemental analysis, TG, IR, UV–vis., EPR, magnetic, and conductance measurements) and tested for their antimicrobial activities. H2L is a mono-negative bidentate ligand via hydrazone N and C–O forming intermediate complexes between tetrahedral and square-planar geometries (“flattened” tetrahedron, D 2d symmetry) for 1 and 2, as well as square-planar for Cu(II) complex 3. Natural bond orbital analysis revealed that the interaction of oxygen with metal ion is the main factor which determines the stability of 13 as the binding energy decreases with an increase in the M–O bond length. Time-dependent density functional theory calculations were carried out to understand the electronic transitions in related experimental observations. The reduction potential values of the nitro group are affected by the metal center. Ni(II) complex 2 displayed the highest activity among the tested complexes against Escherichia coli with a MIC50 value of 0.098 μmol mL−1 compared with 0.131 (1) and 0.117 μmol mL−1 (3).
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: MEP; NBO; Nitrofuran; electrochemical; metal complexes

Document Type: Research Article

Affiliations: Faculty of Science, Chemistry Department, Cairo University, Giza, Egypt

Publication date: January 17, 2016

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more