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Ag(I) and Zn(II) isonicotinate complexes: design, characterization, antimicrobial effect, and CT-DNA binding studies

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Trinuclear Ag(I) (1) and dinuclear and mononuclear Zn(II) isonicotinate (2 and 3) complexes were prepared and characterized by X-ray crystallography, elemental analysis, IR spectroscopy, and thermal analysis. Single-crystal analysis of the Ag(I) complex reveals two different monodentate carboxylate coordination modes, protonated and deprotonated, respectively. IR spectra showed correlations between isonicotinate coordination modes and Δ(ν as − ν s)IR values. In addition, the hydrogen bonds significantly influence a position of carboxylate absorption bands. Moreover, IC50 and MIC data for bacteria, yeasts, and filamentous fungi were determined and the binding of Ag(I) and Zn(II) complexes to calf thymus DNA was investigated using electronic absorption, fluorescence, and CD measurements. Biological tests showed that the Ag(I) complex is more active than commercially used Ag(I) sulfadiazine against Escherichia coli. The fluorescence spectral results indicate that the complexes can bind to DNA through an intercalative mode. The Stern–Volmer quenching constants for investigated complexes obtained from the linear quenching plot are in the range of 1.67 × 104–3.42 × 104 M−1.
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Keywords: Ag(I) and Zn(II) complexes; Antimicrobial activity; Fluorescence; Intercalative DNA binding; Isonicotinate; Mid-IR spectra

Document Type: Research Article

Affiliations: 1: Faculty of Science, Department of Inorganic Chemistry, P.J. Šafárik University, Košice, Slovak Republic 2: Faculty of Science, Deparment of Biochemistry, P.J. Šafárik University, Košice, Slovak Republic 3: Department of Biochemistry and Microbiology, Slovak University of Technology, Bratislava, Slovak Republic 4: Faculty of Science, Department of Organic Chemistry, P.J. Šafárik University, Košice, Slovak Republic

Publication date: December 17, 2015

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