Optically pure α-ketoimines were obtained under solvent-free conditions starting from 2,2′-pyridil and (S)-(−)-1-phenylethylamine and (S)-(−)-1-(4-methylphenyl)ethylamine, respectively. These new chiral ketoimines were then complexed with palladium
yielding new optically pure mono-Pd complexes 3A–B. The compounds have been characterized by IR, 1H NMR, and 13C NMR spectroscopies along with MS-FAB+ spectrometry. The crystal and molecular structure of 3A has been fully confirmed by single-crystal
X-ray studies. In vitro studies of 3A–B display growth inhibition against leukemia (K-562 CML), colon cancer (HCT-15), breast cancer (MCF-7), central nervous system (U-251 Glio), and prostate cancer (PC-3) cancer cell lines.
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Document Type: Research Article
Lab. Síntesis de Complejos. Fac. Ciencias Químicas, Universidad Autónoma de Puebla, Puebla, Mexico
Instituto de Física Luis Rivera Terrazas, BUAP, Puebla, Mexico
Ingeniería Bioquímica, Instituto Tecnológico Superior de Atlixco, Atlixco, Mexico
Instituto de Química-UNAM, Circuito exterior, Cd. Universitaria, Coyoacán, México, DF, Mexico
Publication date: November 2, 2015