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Synthesis, crystal structure, spectroscopy, and nuclease activity of copper(II) complexes containing N,N-bis(2-pyridylmethyl)amine ligand

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[Cu(bpea)Cl]ClO4 (1) and a new copper(II) complex [Cu(bpma)(Ph-COO)(H2O)]ClO4 (2) [bpea = N,N-bis(2-pyridylmethyl)ethylamine; bpma = N,N-bis(2-pyridylmethyl)methylamine] have been synthesized. Complex 2 was crystallized in monoclinic space group P21/c with unit cell parameters a = 16.460(6) Å, b = 11.222(4) Å, c = 12.522(5) Å, and β = 97.985(6)°. Interactions of the complexes with calf thymus DNA (CT-DNA) have been investigated by UV absorption, fluorescence, and cyclic voltammetry; thus, modes of CT-DNA binding for the complexes have been proposed. Furthermore, DNA cleavage activities by the complexes were performed in the absence of any external agents. The influence of complex concentration or reaction time on the DNA cleavage was studied.
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Keywords: Copper complex; Crystal structure; DNA binding; DNA cleavage

Document Type: Research Article

Affiliations: 1: College of Chemistry, Tianjin Normal University, 300387, Tianjin, P.R. China 2: Department of Chemistry, Baoding College, 071000, Baoding, P.R. China 3: Department of Chemistry, Nankai University, 300071, Tianjin, P.R. China

Publication date: June 1, 2011

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