A cationic porphyrin-anthraquinone hybrid and its Zn(II), Cu(II), Co(III), and Mn(III) complexes were synthesized and their interactions with duplex DNA were studied using a combination of absorption, fluorescence titration, circular dichroism spectroscopy, thermal DNA denaturation,
viscosity measurements, gel electrophoresis, and gas chromatography. Metal coordination induces intermolecular steric hindrance and thus the metal hybrids have smaller DNA binding affinities than the free base hybrid; the steric hindrance could relax the intermolecular aggregation and increase
1O2 generation of the metal hybrids. The DNA photocleavage abilities of these hybrids were investigated.
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Document Type: Research Article
School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, P.R. China
MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, P.R. China
Publication date: June 1, 2011