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Metal complexes of porphyrin-anthraquinone hybrids: DNA binding and photocleavage specificities

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A cationic porphyrin-anthraquinone hybrid and its Zn(II), Cu(II), Co(III), and Mn(III) complexes were synthesized and their interactions with duplex DNA were studied using a combination of absorption, fluorescence titration, circular dichroism spectroscopy, thermal DNA denaturation, viscosity measurements, gel electrophoresis, and gas chromatography. Metal coordination induces intermolecular steric hindrance and thus the metal hybrids have smaller DNA binding affinities than the free base hybrid; the steric hindrance could relax the intermolecular aggregation and increase 1O2 generation of the metal hybrids. The DNA photocleavage abilities of these hybrids were investigated.
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Keywords: DNA photocleavage; DNA-binding; Porphyrin-anthraquinone hybrid; Steric hindrance

Document Type: Research Article

Affiliations: 1: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, P.R. China 2: MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, P.R. China

Publication date: June 1, 2011

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