Study on the interaction of lanthanum(III) with adrenaline

Lanthanum(III) equilibria in the presence of adrenaline have been investigated by potentiometric titration under physiological conditions (37°C and an ionic strength of 0.15?M NaCl). The interaction of lanthanum(III) with adrenaline has also been studied using an ab initio method. The complex species in the lanthanum(III)–adrenaline system have been ascertained and the protonation constants for adrenaline and the stability constants for lanthanum(III) complexes with adrenaline have been obtained. Adrenaline can form stable lanthanum(III) complexes with the phenolic hydroxyl group of adrenaline as the binding site of lanthanum(III).