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Home / Journal of Asian Natural Products Research, Volume 21, Number 9

Nimbandiolactone-21 and nimbandioloxyfuran, two new 28-norlimonoids from the leaves of Azadirachta indica (Meliaceae)

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From an EtOAc-soluble fraction of the leaves of Azadirachta indica, two new 28-norlimonoids named nimbandiolactone-21 (1) and nimbandioloxyfuran (2), together with nimbandiolactone-23 (3), were isolated. Their relative structures were elucidated based on NMR spectroscopic interpretation and biosynthetic consideration. Nimbandioloxyfuran (2) and nimbandiolactone-23 (3) showed potent α-glucosidase inhibitory activity, with the IC50 values of 46.2 and 38.7 μM, respectively.

Keywords: 28-norlimonoid; Azadirachta indica; Meliaceae; α-glucosidase inhibitory

Document Type: Research Article

Affiliations: 1: Faculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, 700000, Vietnam 2: Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, 700000, Vietnam 3: Theoretical Physics Research Group, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam

Publication date: 02 September 2019

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