Berberine hydrochloride counteracts enhanced IL-8 expression induced by SN 38 in AGS cells
IL-8 over-expression could enhance cancer metastasis. In present study, berberine hydrochloride (BER) triggered proliferative inhibition and G2/M arrest in AGS cells, down-regulated protein expression of cyclin B1, Bcl-2, up-regulated expression of p21, p53 and cleaved caspase 3, but
showed no effect on protein expression of CHOP, Bip, and caspase 4. BER could down-regulate the enhanced IL-8 expression through down-regulating ERK1/2 and p38 MAPK over-activation induced by SN 38. The increased IL-8 mediated adhesive ability of AGS cells to HUVECs induced by SN 38, could
be reduced by BER. Thus, BER could reduce the side-effect of SN 38 in clinic.
Keywords: AGS cells; IL-8; SN 38; adhesion; berberine hydrochloride
Document Type: Research Article
Affiliations: 1: Gamaknife Center, No 411 Hospital of the Chinese People’s Liberation Army, Shanghai, 200081, China 2: Department of Liver Surgery, Fudan University Shanghai Cancer Center, Cancer Hospital, Shanghai, 200032, China 3: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China 4: Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200433, China
Publication date: 03 August 2018
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