New secoiridoids from the fruits of Ligustrum lucidum
Three new secoiridoids, nuezhenelenoliciside (1), isojaslanceoside B (2), 6′-O-trans-cinnamoyl-secologanoside (3), were isolated from the dried fruits of Ligustrum lucidum. Their structures were elucidated by comprehensive spectroscopic analysis.
Among them, 1 featured a rare rearrangement product of secoiridoid, which underwent the cleavage of chemical bond between C-1 and O-2, and the reformation of a new iridoid ring between C-8 and O-2. In addition, all compounds were tested for their osteogenic activity on pre-osteoblastic
MC3T3-E1 cells. As a result, 1 and 3 exhibited potent effects on promoting cell proliferation of pre-osteoblast cells.
Keywords: MC3T3-E1 cells; Oleaceae; ligustri lucidi fructus; osteogenic activity; secoiridoids
Document Type: Research Article
Affiliations: 1: Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China 2: Key Laboratory of Standard Material in Natural Medicine of Guangdong Province, Guangzhou, 510530, China 3: Shenzhen Research Institute of the Hong Kong Polytechnic University, State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, 518057, China
Publication date: 04 May 2018
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