Isolation and characterization of a new bioactive isoflavone from Derris eriocarpa
Derris eriocarpa How is an important medicinal plant, which is used as Zhuang ethnomedicine and Dai ethnomedicine to treat various diseases. One new compound, 3′,4′-di-O-methylene-5-hydroxy-7-methoxy-6-isopentenyl isoflavone (1) and a known synthetic
but new naturally occurring compound trans-3,4,5-trimethoxy-4′-isopentenyloxyl-stilbene (2), together with five known compounds, 5,7-dimethoxy-6-(3-methyl-2-butenyl)-4′-hydroxyl isoflavones (3), robustone (4), trans-3,4,5,4′-tetramethoxy-stilbene
(5), robustic acid (6), and robustin (7) were isolated from the stem of D. eriocarpa. Spectroscopic analysis revealed the chemical structures of compounds 1–7.. Compounds 1 and 3 exhibited significant scavenging activities against
1,1-diphenyl-2-picrylhydrazyl radical and superoxide anions. Compounds 1–3 exhibited potent antiproliferative activity on Hela cells.
Keywords: Derris eriocarpa; antioxidant activity; antiproliferative activity; isoflavone; stilbene
Document Type: Research Article
Affiliations: 1: Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning, 530008, China 2: Guangxi Key Laboratory of Utilization of Microbial and Botanical Resources, Guangxi University for Nationalities, Nanning, 530008, China
Publication date: 03 October 2015
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