Wilfordonols A–D: four new norsesquiterpenes from the leaves of Tripterygium wilfordii
Four new norsesquiterpenes wilfordonols A–D (1–4), along with three known compounds, sarmentol B (5), boscialin (6), and (+)-loliolide (7), were isolated from the leaves of Tripterygium wilfordii Hook.f.. The structures of the new
compounds were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of the compounds was confirmed by CD and modified Mosher's method. At a concentration of 10 μM, compounds 4, 6, and 7 inhibited signal transducer and activator
of transcription 1 translocation by 34.27 ± 1.02%, 48.93 ± 1.76%, and 70.31 ± 2.20%, respectively.
Keywords: STAT 1; Tripterygium wilfordii; norsesquiterpene; wilfordonols A–D
Document Type: Research Article
Affiliations: 1: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China 2: Chongqing Academy of Chinese Materia Medica, Chongqing, 400065, China
Publication date: 03 June 2015
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