Bufadienolides and polyhydroxycholestane derivatives from Bufo bufo gargarizans
A new polyhydroxycholestane sulfate ester, 3α,12β,25,26-tetrahydroxy-7-oxo-5β-cholestane 26-O-sulfate (1), was isolated from dried skin of Bufo bufo gargarizans Cantor and its structure was elucidated on the basis of extensive 1D and
2D NMR as well as HR-ESI-MS analysis. A comparison of steroidal metabolite profiles, based on HPLC and LC–MS analyses, indicates that the chemical compositions of the various parts of toads, such as venom, skin and stratum corneum, are significantly different.
Keywords: Bufo bufo gargarizans; bufadienolide; polyhydroxycholestane sulfate; toad skin; toad venom
Document Type: Research Article
Affiliations: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China
Publication date: 03 April 2015
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