Two new dendrocandins with neurite outgrowth-promoting activity from Dendrobium officinale
Two new bibenzyl derivatives, dendrocandin T (1) and dendrocandin U (2), together with eight known bibenzyls, were isolated from the stems of Dendrobium officinale. Those compounds were sent for the first time for central nervous system-related bioassay and the
results indicated that compounds 3, 4, and 5 have a certain degree of neurite outgrowth-promoting activity, and compounds 1, 2, 6, and 7 also have weak activity. The results indicated that D. officinale used as health food and traditional
Chinese medicine “Tiepi Shihu” has a health function of neurotrophic effects.
Keywords: Dendrobium officinale; bibenzyl; dendrocandin T; dendrocandin U; neurite outgrowth-promoting activity
Document Type: Research Article
Affiliations: 1: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming,650201, China 2: College of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei,230038, China 3: Key Laboratory of Puer Tea Science, Yunnan Agricultural University, Ministry of Education, Kunming,650201, China
Publication date: 01 February 2015
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