Paeoniflorin acts as a liver X receptor agonist
Paeoniflorin is one of the active ingredients of Paeonia lactiflora Pall., a novel traditional herbal medicine exerting pharmacological effects including antihyperlipidemic, neuroprotective, and anti-hepatofibrosis effects. Liver X receptor (LXR) acts as a ligand-activated transcription
factor to exhibit antihyperlipidemic and neuroprotective effects. In this study, the activity of paeoniflorin against LXR was evaluated by the mammalian one-hybrid and transient transfection reporter assays. The results showed that paeoniflorin transactivated GAL4, rat cholesterol 7 α-hydroxylase,
phospholipid transfer protein, and ATP-binding cassette A1 gene promoters in dose-dependent manner. Furthermore, the docking study demonstrated that paeoniflorin resided in the LXR ligand-binding pocket in the similar manner as GSK 3987, a novel LXR agonist. These results indicated that paeoniflorin
might exert pharmacological effects through LXR pathway.
Keywords: Paeonia lactiflora (Paeoniaceae); liver X receptor (LXR); paeoniflorin
Document Type: Research Article
Affiliations: Department of Chemistry,College of Science, National Kaohsiung Normal University, Taiwan,
Publication date: 01 January 2013
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