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Chalcone-derived Diels–Alder adducts as NF-κB inhibitors from Morus alba

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A bioassay-guided phytochemical fractionation of the methanol extract of the Morus alba root barks led to the isolation of two chalcone-derived Diels–Alder adducts (1 and 2). Their structures were elucidated as kuwanon J 2,4,10″-trimethyl ether (1) and kuwanon R (2) by means of spectroscopic methods. Both compounds strongly inhibited nuclear transcription factor.κB activity with the IC50 values of 4.65 and 7.38 μM, respectively.
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Keywords: Moraceae; Morus alba; NF-κB; chalcone-derived Diels–Alder

Document Type: Research Article

Affiliations: 1: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam 2: Institute of Natural Product Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam

Publication date: June 1, 2012

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