A bioassay-guided phytochemical fractionation of the methanol extract of the Morus alba root barks led to the isolation of two chalcone-derived Diels–Alder adducts (1 and 2). Their structures were elucidated as kuwanon J 2,4,10″-trimethyl ether (1)
and kuwanon R (2) by means of spectroscopic methods. Both compounds strongly inhibited nuclear transcription factor.κB activity with the IC50 values of 4.65 and 7.38 μM, respectively.
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Document Type: Research Article
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam
Institute of Natural Product Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam
June 1, 2012